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Long non coding RNAs (lncRNAs) are a class of non protein coding RNAs that play a crucial role in most of the biological activities like nodule metabolism, flowering time and male sterility. Quite often, the function of lncRNAs is species-specific in nature.
Thus an attempt has been made in cluster bean (Cyamopsis tetragonoloba) for the first time to computationally identify lncRNAs based on a proposed index and study their interactions with miRNAs. Further, the targeted genes of lncRNAs were identified and characterized for their role in various biological processes. Besides, lncRNAs and miRNAs bearing Simple Sequence Repeat (SSR) were identified that contribute towards biogenesis of small non-coding RNAs. Moreover, five novel endogenous Target Mimic (eTM) lncRNAs were identified from the interaction between putative lncRNAs and miRNAs. The predicted lncRNAs are found to involve in regulating various stress mechanisms, DNA damage repair and cell wall synthesis.
"This work was supported by the grants ICAR-Consortia Research Platform on Genomics (CRP-Genomics/IX/2017) and CABin Scheme Network project on Agricultural Bioinformatics and Computational Biology (F.No. Agril.Edn. 14/2/2017-A&P dated 02.08.2017), received from Indian Council of Agricultural Research (ICAR)"
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